About the CMS

Device fabrication, cell perfusion culture, and cell imaging in one site.

Device fabrication, cell perfusion culture, and cell imaging.

The Centre for Microfluidic Systems in Chemistry and Biology, aka the CMS, was a proposal written by Professors from the University of Toronto and York University and funded by the Canadian Foundation for Innovation. This group of researchers proposed making a centre to facilitate two research efforts:

1. Integrated Platforms for biomolcular screening and cardiovascular drug discovery

2. New therapies aimed at the treatment of myocardial infarction and heart failure

To tackle these two areas of research, team proposed to create advanced microfluidic platforms that would leverage the advantages of studying at the micron-length scale such as high mass and heat transfer, high yield, and the ability to scale up production of new products; while integrating automated microfluidic synthesis of therapeutics, physiologically-relevant cell-based screening, and on-chip bio-molecular analysis and screening. The microfluidic platforms would consist of three components:
1. Microscale reactors that optimize and dramatically accelerate the rate of new small molecule synthesis through multi-step reactions and processes that are automated, continuous and scale-able;
2. Devices for cell-based screening configured as multi-layered microchannel/microwell networks that mimic key features of the blood vessel wall;
3. On-line analytical systems for rapid and high-throughput identification of high-affinity binding molecules and protein binding small molecules.

The centre would run as 3 open access laboratories with unique specializations in:
1. Flow Chemistry
2. Fabrication of Microreactors, Sensors and Actuators
3. Microfluidics Foundry, Cell Perfusion Culture and Imaging